MTICF Publications

Unraveling the dynamics of B7-H3-targeting therapeutic antibodies in cancer through PET imaging and antibody pharmacokinetics.

Fernandes BOlkowski CPGhaemi BBasuli FShi JKiesewetter DOLang LElijah ESwenson RChoyke PLLin FIJacobson O

J Control Release

2025 Mar 10

A Type I Photosensitizer-Polymersome Boosts Reactive Oxygen Species Generation by Forcing H-Aggregation for Amplifying STING Immunotherapy.

Wang ZMa WYang ZKiesewetter DOWu YLang LZhang GNakuchima SChen JSu YHan SWu LGJin AJHuang W

J Am Chem Soc

2024 Oct 23

Distributable, metabolic PET reporting of tuberculosis.

Khan RMNAhn YMMarriner GAVia LED'Hooge FSeo Lee SYang NBasuli FWhite AGTomko JAFrye LJScanga CAWeiner DMSutphen MLSchimel DMDayao EPiazza MKGomez FDieckmann WHerscovitch PMason NSSwenson RKiesewetter DOBackus KMGeng YRaj RAnthony DCFlynn JLBarry CEDavis BG

Nat Commun

2024 Jun 27

Distributable, Metabolic PET Reporting of Tuberculosis.

Naseer Khan RMAhn YMMarriner GAVia LED'Hooge FLee SSYang NBasuli FWhite AGTomko JAFrye LJScanga CAWeiner DMSutphen MLSchimel DMDayao EPiazza MKGomez FDieckmann WHerscovitch PMason NSSwenson RKiesewetter DOBackus KMGeng YRaj RAnthony DCFlynn JLBarry CEDavis BG

bioRxiv

2023 Apr 03

Array

Thakur SDaley BMillo CCochran CJacobson OLu HWang ZKiesewetter DChen XVasko VKlubo-Gwiezdzinska J

Clin Cancer Res

2021 Mar 01

Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics.

Tian RZeng QZhu SLau JChandra SErtsey RHettie KSTeraphongphom THu ZNiu GKiesewetter DOSun HZhang XAntaris ALBrooks BRChen X

Sci Adv

2019 Sep

3-F-fluoropropane-1-thiol and F-PEG-1-thiol: Versatile prosthetic groups for radiolabeling maleimide functionalized peptides.

Jacobson OWang ZYu GMa YChen XKiesewetter DO

Bioorg Med Chem

2019 Oct 01

Organosilica-Based Hollow Mesoporous Bilirubin Nanoparticles for Antioxidation-Activated Self-Protection and Tumor-Specific Deoxygenation-Driven Synergistic Therapy.

Shan LFan WWang WTang WYang ZWang ZLiu YShen ZDai YCheng SJacobson OZhai KHu JMa YKiesewetter DOGao GChen X

ACS Nano

2019 Aug 27

In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimulus-responsive intracellular drug delivery.

Liu YGong CSDai YYang ZYu GLiu YZhang MLin LTang WZhou ZZhu GChen JJacobson OKiesewetter DOWang ZChen X

Biomaterials

2019 Oct

Tumor Microenvironment-Activated Ultrasensitive Nanoprobes for Specific Detection of Intratumoral Glutathione by Ratiometric Photoacoustic Imaging.

Tang LYu FTang BYang ZFan WZhang MWang ZJacobson OZhou ZLi LLiu YKiesewetter DOTang WHe LMa YNiu GZhang XChen X

ACS Appl Mater Interfaces

2019 Aug 07

Improving the Theranostic Potential of Exendin 4 by Reducing the Renal Radioactivity through Brush Border Membrane Enzyme-Mediated Degradation.

Zhang MJacobson OKiesewetter DOMa YWang ZLang LTang LKang FDeng HYang WNiu GWang JChen X

Bioconjug Chem

2019 Jun 19

An Albumin Sandwich Enhances in Vivo Circulation and Stability of Metabolically Labile Peptides.

Tian RZhu SZeng QLang LMa YKiesewetter DOLiu YFu XLau JZhu GJacobson OWang ZDai YYu GBrooks BRLiu GNiu GChen X

Bioconjug Chem

2019 Jun 19

A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy.

Tang LYang ZZhou ZMa YKiesewetter DOWang ZFan WZhu SZhang MTian RLang LNiu GZhang XChen X

Theranostics

2019

In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy.

Yang WZhu GWang SYu GYang ZLin LZhou ZLiu YDai YZhang FShen ZLiu YHe ZLau JNiu GKiesewetter DOHu SChen X

ACS Nano

2019 Mar 26

Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery.

Tian RMa HYang QWan HZhu SChandra SSun HKiesewetter DONiu GLiang YChen X

Chem Sci

2019 Jan 07

Antidiabetic Effect of Abextide, a Long-Acting Exendin-4 Analogue in Cynomolgus Monkeys.

Niu GWang GLau JLang LJacobson OMa YKiesewetter DOZhang SChen X

Adv Healthc Mater

2019 Jun

Single Low-Dose Injection of Evans Blue Modified PSMA-617 Radioligand Therapy Eliminates Prostate-Specific Membrane Antigen Positive Tumors.

Wang ZTian RNiu GMa YLang LSzajek LPKiesewetter DOJacobson OChen X

Bioconjug Chem

2018 Sep 19

Automated radiosynthesis of [F]FBEM, a sulfhydryl site specific labeling agent for peptides and proteins.

Lim KRopchan JKiesewetter DOChen XHuang Y

Appl Radiat Isot

2018 Oct

Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging.

Zhu SHu ZTian RYung BCYang QZhao SKiesewetter DONiu GSun HAntaris ALChen X

Adv Mater

2018 Jul 09

Radioligand Therapy of Prostate Cancer with a Long-Lasting Prostate-Specific Membrane Antigen Targeting Agent Y-DOTA-EB-MCG.

Wang ZJacobson OTian RMease RCKiesewetter DONiu GPomper MGChen X

Bioconjug Chem

2018 Jul 18

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat.

Thompson SJPitcher MHStone LSTarum FNiu GChen XKiesewetter DOSchweinhardt PBushnell MC

Pain

2018 Sep

A paclitaxel prodrug with bifunctional folate and albumin binding moieties for both passive and active targeted cancer therapy.

Shan LZhuo XZhang FDai YZhu GYung BCFan WZhai KJacobson OKiesewetter DOMa YGao GChen X

Theranostics

2018

Evans Blue Attachment Enhances Somatostatin Receptor Subtype-2 Imaging and Radiotherapy.

Tian RJacobson ONiu GKiesewetter DOWang ZZhu GMa YLiu GChen X

Theranostics

2018

Engineered Zn(II)-Dipicolylamine-Gold Nanorod Provides Effective Prostate Cancer Treatment by Combining siRNA Delivery and Photothermal Therapy.

Min KHKim YHWang ZKim JKim JSKim SHKim KKwon ICKiesewetter DOChen X

Theranostics

2017

Quantification of Tumor Vascular Permeability and Blood Volume by Positron Emission Tomography.

Chen HTong XLang LJacobson OYung BCYang XBai RKiesewetter DOMa YWu HNiu GChen X

Theranostics

2017

PET-Guided Evaluation and Optimization of Internalized Antibody-Drug Conjugates Targeting Erythropoietin-Producing Hepatoma A2 Receptor.

Jacobson OLi QChen HNiu GKiesewetter DOXu LCook KYang GDall'Acqua WTsui PPeng LChen X

J Nucl Med

2017 Nov

Correction to "Novel F Activatable Probe for the Detection of Matrix Metalloprotease-2 Activity by MRI/MRS".

Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X

Mol Pharm

2017 Apr 03

Novel "Add-On" Molecule Based on Evans Blue Confers Superior Pharmacokinetics and Transforms Drugs to Theranostic Agents.

Chen HJacobson ONiu GWeiss IDKiesewetter DOLiu YMa YWu HChen X

J Nucl Med

2017 Apr

Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery.

Tong XWang ZSun XSong JJacobson ONiu GKiesewetter DOChen X

Theranostics

2016

Albumin-Binding Evans Blue Derivatives for Diagnostic Imaging and Production of Long-Acting Therapeutics.

Jacobson OKiesewetter DOChen X

Bioconjug Chem

2016 Oct 19

Monitoring Tumor Hypoxia Using (18)F-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy.

Tong XSrivatsan AJacobson OWang YWang ZYang XNiu GKiesewetter DOZheng HChen X

Sci Rep

2016 Aug 22

A photothermally responsive nanoprobe for bioimaging based on Edman degradation.

Liu YWang ZZhang HLang LMa YHe QLu NHuang PLiu YSong JLiu ZGao SMa QKiesewetter DOChen X

Nanoscale

2016 May 19

Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding.

Chen HWang GLang LJacobson OKiesewetter DOLiu YMa YZhang XWu HZhu LNiu GChen X

Theranostics

2016

Glucagon-Like Peptide-1 Receptor PET/CT with 68Ga-NOTA-Exendin-4 for Detecting Localized Insulinoma: A Prospective Cohort Study.

Luo YPan QYao SYu MWu WXue HKiesewetter DOZhu ZLi FZhao YChen X

J Nucl Med

2016 May

68Ga-NOTA-Exendin-4 PET/CT in Localization of an Occult Insulinoma and Appearance of Coexisting Esophageal Carcinoma.

Luo YLi NKiesewetter DOChen XLi F

Clin Nucl Med

2016 Apr

Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.

Liu YWang GZhang HMa YLang LJacobson OKiesewetter DOZhu LGao SMa QChen X

Bioconjug Chem

2016 Jan 20

Al[18F]NOTA-T140 Peptide for Noninvasive Visualization of CXCR4 Expression.

Yan XNiu GWang ZYang XKiesewetter DOJacobson OShen BChen X

Mol Imaging Biol

2016 Feb

Boramino acid as a marker for amino acid transporters.

Liu ZChen HChen KShao YKiesewetter DONiu GChen X

Sci Adv

2015 Sep

NIR-Responsive On-Demand Release of CO from Metal Carbonyl-Caged Graphene Oxide Nanomedicine.

He QKiesewetter DOQu YFu XFan JHuang PLiu YZhu GLiu YQian ZChen X

Adv Mater

2015 Nov

18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression.

Jacobson OWeiss IDWang LWang ZYang XDewhurst AMa YZhu GNiu GKiesewetter DOVasdev NLiang SHChen X

J Nucl Med

2015 Nov

One-step (18)F labeling of biomolecules using organotrifluoroborates.

Liu ZLin KSBénard FPourghiasian MKiesewetter DOPerrin DMChen X

Nat Protoc

2015 Sep

Novel Method for Radiolabeling and Dimerizing Thiolated Peptides Using (18)F-Hexafluorobenzene.

Jacobson OYan XMa YNiu GKiesewetter DOChen X

Bioconjug Chem

2015 Oct 21

Design of a functional cyclic HSV1-TK reporter and its application to PET imaging of apoptosis.

Wang ZWang FHida NKiesewetter DOTian JNiu GChen X

Nat Protoc

2015 May

Quantitative Evaluation of Tumor Early Response to a Vascular-Disrupting Agent with Dynamic PET.

Guo NZhang FZhang XGuo JLang LKiesewetter DONiu GLi QChen X

Mol Imaging Biol

2015 Dec

PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer.

Jacobson OYan XNiu GWeiss IDMa YSzajek LPShen BKiesewetter DOChen X

J Nucl Med

2015 Apr

Intrinsically radioactive [64Cu]CuInS/ZnS quantum dots for PET and optical imaging: improved radiochemical stability and controllable Cerenkov luminescence.

Guo WSun XJacobson OYan XMin KSrivatsan ANiu GKiesewetter DOChang JChen X

ACS Nano

2015 Jan 27

In vivo albumin labeling and lymphatic imaging.

Wang YLang LHuang PWang ZJacobson OKiesewetter DOAli IUTeng GNiu GChen X

Proc Natl Acad Sci U S A

2015 Jan 06

Fluorine-18 radiochemistry, labeling strategies and synthetic routes.

Jacobson OKiesewetter DOChen X

Bioconjug Chem

2015 Jan 21

68Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake.

Luo YYu MPan QWu WZhang TKiesewetter DOZhu ZLi FChen XZhao Y

Eur J Nucl Med Mol Imaging

2015 Mar

Bioinspired nanocomplex for spatiotemporal imaging of sequential mRNA expression in differentiating neural stem cells.

Wang ZZhang RWang ZWang HFWang YZhao JWang FLi WNiu GKiesewetter DOChen X

ACS Nano

2014 Dec 23

Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS.

Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X

Mol Pharm

2014 Nov 03

[(18)F]DPA-714 PET imaging of AMD3100 treatment in a mouse model of stroke.

Wang YYue XKiesewetter DOWang ZLu JNiu GTeng GChen X

Mol Pharm

2014 Oct 06

Chelator-free (64)Cu-integrated gold nanomaterials for positron emission tomography imaging guided photothermal cancer therapy.

Sun XHuang XYan XWang YGuo JJacobson OLiu DSzajek LPZhu WNiu GKiesewetter DOSun SChen X

ACS Nano

2014 Aug 26

In Vivo Labeling of Serum Albumin for PET.

Niu GLang LKiesewetter DOMa YSun ZGuo NGuo JWu CChen X

J Nucl Med

2014 Jul

One-pot two-step radiosynthesis of a new (18)F-labeled thiol reactive prosthetic group and its conjugate for insulinoma imaging.

Yue XYan XWu CNiu GMa YJacobson OShen BKiesewetter DOChen X

Mol Pharm

2014 Nov 03

A symmetrical fluorous dendron-cyanine dye-conjugated bimodal nanoprobe for quantitative 19F MRI and NIR fluorescence bioimaging.

Wang ZYue XWang YQian CHuang PLizak MNiu GWang FRong PKiesewetter DOMa YChen X

Adv Healthc Mater

2014 Aug

Retraction note to: Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. Age (2012) 35(3): 597-608.

Gao FTaha AYMa KChang LKiesewetter DRapoport SI

Age (Dordr)

2014 Jun

A cyclic HSV1-TK reporter for real-time PET imaging of apoptosis.

Wang FWang ZHida NKiesewetter DOMa YYang KRong PLiang JTian JNiu GChen X

Proc Natl Acad Sci U S A

2014 Apr 08

Longitudinal PET imaging of muscular inflammation using 18F-DPA-714 and 18F-Alfatide II and differentiation with tumors.

Wu CYue XLang LKiesewetter DOLi FZhu ZNiu GChen X

Theranostics

2014

PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714.

Wang YYue XKiesewetter DONiu GTeng GChen X

Eur J Nucl Med Mol Imaging

2014 Jul

Stability analysis of glutamic acid linked peptides coupled to NOTA through different chemical linkages.

Lang LMa YKiesewetter DOChen X

Mol Pharm

2014 Nov 03

Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy.

Rong PYang KSrivastan AKiesewetter DOYue XWang FNie LBhirde AWang ZLiu ZNiu GWang WChen X

Theranostics

2014

Self-illuminating 64Cu-doped CdSe/ZnS nanocrystals for in vivo tumor imaging.

Sun XHuang XGuo JZhu WDing YNiu GWang AKiesewetter DOWang ZLSun SChen X

J Am Chem Soc

2014 Feb 05

Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity.

Zhu LMa YKiesewetter DOWang YLang LLee SNiu GChen X

ACS Chem Biol

2014 Feb 21

(18)F-alfatide II and (18)F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy.

Guo JGuo NLang LKiesewetter DOXie QLi QEden HSNiu GChen X

J Nucl Med

2014 Jan

Comparison of three dimeric 18F-AlF-NOTA-RGD tracers.

Guo JLang LHu SGuo NZhu LSun ZMa YKiesewetter DONiu GXie QChen X

Mol Imaging Biol

2014 Apr

Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas.

Yue XKiesewetter DOGuo JSun ZZhang XZhu LNiu GMa YLang LChen X

Bioconjug Chem

2013 Jul 17

Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging.

Wang ZZhang XHuang PZhao WLiu DNie LYue XWang SMa YKiesewetter DNiu GChen X

Biomaterials

2013 Aug

Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression.

Zhang XXSun ZGuo JWang ZWu CNiu GMa YKiesewetter DOChen X

Mol Imaging Biol

2013 Dec

pH-sensitive fluorescent dyes: are they really pH-sensitive in cells?

Zhang XXWang ZYue XMa YKiesewetter DOChen X

Mol Pharm

2013 May 06

Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver.

Gao FTaha AYMa KChang LKiesewetter DRapoport SI

Age (Dordr)

2013 Jun

Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma.

Kiesewetter DOGuo NGuo JGao HZhu LMa YNiu GChen X

Theranostics

2012

PET of glucagonlike peptide receptor upregulation after myocardial ischemia or reperfusion injury.

Gao HKiesewetter DOZhang XHuang XGuo NLang LHida NWang HWang HCao FNiu GChen X

J Nucl Med

2012 Dec

The synthesis and in vivo pharmacokinetics of fluorinated arachidonic acid: implications for imaging neuroinflammation.

Pichika RTaha AYGao FKotta KCheon YChang LKiesewetter DRapoport SIEckelman WC

J Nucl Med

2012 Sep

Site-Specific Labeling of scVEGF with Fluorine-18 for Positron Emission Tomography Imaging.

Wang HGao HGuo NNiu GMa YKiesewetter DOChen X

Theranostics

2012

Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model.

Guo NLang LLi WKiesewetter DOGao HNiu GXie QChen X

PLoS One

2012

PET of HER2-positive pulmonary metastases with 18F-ZHER2:342 affibody in a murine model of breast cancer: comparison with 18F-FDG.

Kramer-Marek GBernardo MKiesewetter DOBagci UKuban MAras OZielinski RSeidel JChoyke PCapala J

J Nucl Med

2012 Jun

Quantitative analysis and parametric imaging of 18F-labeled monomeric and dimeric RGD peptides using compartment model.

Guo NLang LGao HNiu GKiesewetter DOXie QChen X

Mol Imaging Biol

2012 Dec

Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes.

Huang XZhang FLee SSwierczewska MKiesewetter DOLang LZhang GZhu LGao HChoi HSNiu GChen X

Biomaterials

2012 Jun

Potential of PET to predict the response to trastuzumab treatment in an ErbB2-positive human xenograft tumor model.

Kramer-Marek GGijsen MKiesewetter DOBennett RRoxanis IZielinski RKong ACapala J

J Nucl Med

2012 Apr

Longitudinal PET imaging of doxorubicin-induced cell death with 18F-Annexin V.

Hu SKiesewetter DOZhu LGuo NGao HLiu GHida NLang LNiu GChen X

Mol Imaging Biol

2012 Dec

Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS.

Ma YYang MGao HNiu GYan YLang LKiesewetter DOChen X

Amino Acids

2012 Oct

PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2.

Gao HLang LGuo NCao FQuan QHu SKiesewetter DONiu GChen X

Eur J Nucl Med Mol Imaging

2012 Apr

N-Succinimidyl 4-[(18)F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression.

Li WLang LNiu GGuo NMa YKiesewetter DOShen BChen X

Amino Acids

2012 Sep

18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma.

Kiesewetter DOGao HMa YNiu GQuan QGuo NChen X

Eur J Nucl Med Mol Imaging

2012 Mar

Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.

Liu GChoi KYBhirde ASwierczewska MYin JLee SWPark JHHong JIXie JNiu GKiesewetter DOLee SChen X

Angew Chem Int Ed Engl

2012 Jan 09

PET imaging of EGF receptors using [18F]FBEM-EGF in a head and neck squamous cell carcinoma model.

Li WNiu GLang LGuo NMa YKiesewetter DOBacker JMShen BChen X

Eur J Nucl Med Mol Imaging

2012 Feb

Improvement of CXCR4 tracer specificity for PET imaging.

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOPeled AEden HSFarber JMChen X

J Control Release

2012 Jan 30

Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma.

Martiniova LCleary SLai EWKiesewetter DOSeidel JDawson LFPhillips JKThomasson DChen XEisenhofer GPowers JFKvetnansky RPacak K

Nucl Med Biol

2012 Feb

Imaging of the muscarinic acetylcholine neuroreceptor in rats with the M2 selective agonist [18F]FP-TZTP.

Ravasi LTokugawa JNakayama TSeidel JSokoloff LEckelman WCKiesewetter DO

Nucl Med Biol

2012 Jan

Positron emission tomography imaging of tumors expressing the human chemokine receptor CXCR4 in mice with the use of 64Cu-AMD3100.

Weiss IDJacobson OKiesewetter DOJacobus JPSzajek LPChen XFarber JM

Mol Imaging Biol

2012 Feb

Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice.

Lang LLi WGuo NMa YZhu LKiesewetter DOShen BNiu GChen X

Bioconjug Chem

2011 Dec 21

New Methods for Labeling RGD Peptides with Bromine-76.

Lang LLi WJia HMFang DCZhang SSun XZhu LMa YShen BKiesewetter DONiu GChen X

Theranostics

2011

Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.

Bhattacharjee AKLang LJacobson OShinkre BMa YNiu GTrenkle WCJacobson KAChen XKiesewetter DO

Nucl Med Biol

2011 Aug

PET of insulinoma using ¹⁸F-FBEM-EM3106B, a new GLP-1 analogue.

Gao HNiu GYang MQuan QMa YMurage ENAhn JMKiesewetter DOChen X

Mol Pharm

2011 Oct 03

Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet.

Gao FKim HWIgarashi MKiesewetter DChang LMa KRapoport SI

Biochim Biophys Acta

2011

PET imaging of CXCR4 using copper-64 labeled peptide antagonist.

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOFarber JMChen X

Theranostics

2011

Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain.

Jacobson OWeiss IDNiu GBalboni GCongiu COnnis VKiesewetter DOLattanzi RSalvadori SChen X

J Nucl Med

2011 Apr

PET imaging of early response to the tyrosine kinase inhibitor ZD4190.

Yang MGao HYan YSun XChen KQuan QLang LKiesewetter DNiu GChen X

Eur J Nucl Med Mol Imaging

2011 Jul

Rapid and simple one-step F-18 labeling of peptides.

Jacobson OZhu LMa YWeiss IDSun XNiu GKiesewetter DOChen X

Bioconjug Chem

2011 Mar 16

[(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor.

Jagoda EMLang LMcCullough KContoreggi CKim BMMa YRice KCSzajek LPEckelman WCKiesewetter DO

Synapse

2011 Sep

MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides.

Jacobson OZhu LNiu GWeiss IDSzajek LPMa YSun XYan YKiesewetter DOLiu SChen X

Mol Imaging Biol

2011 Dec

Increased uptake of [¹²³I]meta-iodobenzylguanidine, [¹⁸F]fluorodopamine, and [³H]norepinephrine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitors.

Martiniova LPerera SMBrouwers FMAlesci SAbu-Asab MMarvelle AFKiesewetter DOThomasson DMorris JCKvetnansky RTischler ASReynolds JCFojo ATPacak K

Endocr Relat Cancer

2011 Feb

Automated radiochemical synthesis of [18F]FBEM: a thiol reactive synthon for radiofluorination of peptides and proteins.

Kiesewetter DOJacobson OLang LChen X

Appl Radiat Isot

2011 Feb

LC/MS evaluation of metabolism and membrane transport of bombesin peptides.

Gu DMa YNiu GYan YLang LAisa HAGao HKiesewetter DOChen X

Amino Acids

2011 Feb

PET of tumor CXCR4 expression with 4-18F-T140.

Jacobson OWeiss IDKiesewetter DOFarber JMChen X

J Nucl Med

2010 Nov

Quantifying conversion of linoleic to arachidonic and other n-6 polyunsaturated fatty acids in unanesthetized rats.

Gao FKiesewetter DChang LRapoport SIIgarashi M

J Lipid Res

2010 Oct

Applications of LC-MS in PET radioligand development and metabolic elucidation.

Ma YKiesewetter DOLang LGu DChen X

Curr Drug Metab

2010 Jul

Radiolabeling of HER2 specific Affibody(R) molecule with F-18.

Kiesewetter DOKrämer-Marek GMa YCapala J

J Fluor Chem

2008 Sep

Enantiomeric radiochemical synthesis of R and S (1-(6-amino-9H-purin-9-yl)-3-fluoropropan-2-yloxy)methylphosphonic acid (FPMPA).

Kiesewetter DOKnudson KCollins MSrinivasula SLim EDi Mascio M

J Labelled Comp Radiopharm

2008 Mar 13

[18F]FBEM-Z(HER2:342)-Affibody molecule-a new molecular tracer for in vivo monitoring of HER2 expression by positron emission tomography.

Kramer-Marek GKiesewetter DOMartiniova LJagoda ELee SBCapala J

Eur J Nucl Med Mol Imaging

2008 May

Antiretroviral tissue kinetics: in vivo imaging using positron emission tomography.

Di Mascio MSrinivasula SBhattacharjee ACheng LMartiniova LHerscovitch PLertora JKiesewetter D

Antimicrob Agents Chemother

2009 Oct

Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats.

Gao FKiesewetter DChang LMa KRapoport SIIgarashi M

J Lipid Res

2009 Dec

Changes in HER2 expression in breast cancer xenografts after therapy can be quantified using PET and (18)F-labeled affibody molecules.

Kramer-Marek GKiesewetter DOCapala J

J Nucl Med

2009 Jul

Application of highly sensitive UPLC-MS to determine biodistribution at tracer doses: validation with the 5-HT1A ligand [(18)F]FPWAY.

Ma YLang LReyes LTokugawa JJagoda EMKiesewetter DO

Nucl Med Biol

2009 May

64Cu-AMD3100--a novel imaging agent for targeting chemokine receptor CXCR4.

Jacobson OWeiss IDSzajek LFarber JMKiesewetter DO

Bioorg Med Chem

2009 Feb 15

Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography.

Kiesewetter DOLang LMa YBhattacharjee AKGao ZGJoshi BVMelman Ade Castro SJacobson KA

Nucl Med Biol

2009 Jan

Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from circulating unesterified alpha-linolenic acid in unanesthetized rats.

Gao FKiesewetter DChang LMa KBell JMRapoport SIIgarashi M

J Lipid Res

2009 Apr

An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities.

Vuong BKKiesewetter DOLang LMa YEckelman WCChanning MA

Nucl Med Biol

2007 May

Evaluation of [18F]fluoroxanomeline {5-{4-[(6-[18F]fluorohexyl)oxy]-1,2,5-thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydropyridine} in muscarinic knockout mice.

Kiesewetter DOJagoda EMShimoji KMa YEckelman WC

Nucl Med Biol

2007 Feb

Automated synthesis of 18F analogue of paclitaxel (PAC): [18F]Paclitaxel (FPAC).

Kalen JDHirsch JIKurdziel KAEckelman WCKiesewetter DO

Appl Radiat Isot

2007 Jun

Species differences in metabolites of PET ligands: serotonergic 5-HT1A receptor antagonists 3-trans-FCWAY and 3-cis-FCWAY.

Ma YLang LKiesewetter DJagoda EEckelman WC

Nucl Med Biol

2006 Nov

Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder.

Cannon DMCarson RENugent ACEckelman WCKiesewetter DOWilliams JRollis DDrevets MGandhi SSolorio GDrevets WC

Arch Gen Psychiatry

2006 Jul

Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT.

Jagoda EMLang LTokugawa JSimmons AMa YContoreggi CKiesewetter DEckelman WC

Synapse

2006 May

Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxel.

Gangloff AHsueh WAKesner ALKiesewetter DOPio BSPegram MDBeryt MTownsend ACzernin JPhelps MESilverman DH

J Nucl Med

2005 Nov

Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography.

Ma YLang LKiesewetter DOVuong BKChanning MIto YEckelman WC

J Chromatogr A

2004 Apr 23

A potential cholinergic mechanism of procaine's limbic activation.

Benson BECarson REKiesewetter DOHerscovitch PEckelman WCPost RMKetter TA

Neuropsychopharmacology

2004 Jul

Application of LC-MS to the analysis of new radiopharmaceuticals.

Ma YKiesewetter DLang LEckelman WC

Mol Imaging Biol

2003

Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography.

Huang BXChanning MAPlascjak PSKiesewetter DODer MMa YEckelman WC

Nucl Med Biol

2003 Oct

Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow.

Shimoji KEsaki TItoh YRavasi LCook MJehle JJagoda EMKiesewetter DOSchmidt KSokoloff LEckelman WC

Synapse

2003 Nov

Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates.

Kurdziel KAKiesewetter DOCarson REEckelman WCHerscovitch P

J Nucl Med

2003 Aug

Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele.

Cohen RMPodruchny TABokde ALCarson REHerscovitch PKiesewetter DOEckelman WCSunderland T

Synapse

2003 Sep 01

Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions.

Ma YKiesewetter DOLang LDer MHuang BCarson REEckelman WC

Nucl Med Biol

2003 Apr

In vivo muscarinic 2 receptor imaging in cognitively normal young and older volunteers.

Podruchny TAConnolly CBokde AHerscovitch PEckelman WCKiesewetter DOSunderland TCarson RECohen RM

Synapse

2003 Apr

The automated radiosynthesis of [18F]FP-TZTP.

Kiesewetter DOVuong BKChanning MA

Nucl Med Biol

2003 Jan

Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation.

Kiesewetter DOJagoda EMKao CHMa YRavasi LShimoji KSzajek LPEckelman WC

Nucl Med Biol

2003 Jan

Liquid chromatography-tandem mass spectrometry identification of metabolites of three phenylcarboxyl derivatives of the 5-HT(1A) antagonist, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridyl) trans-4-fluorocyclohexanecarboxamide (FCWAY), produced by human and rat hepatocytes.

Ma YLang LKiesewetter DOEckelman WC

J Chromatogr B Analyt Technol Biomed Life Sci

2002 Nov 15

Identification of metabolites of fluorine-18-labeled M2 muscarinic receptor agonist, 3-(3-[(3-fluoropropyl)thio]-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine, produced by human and rat hepatocytes.

Ma YKiesewetter DOJagoda EMHuang BXEckelman WC

J Chromatogr B Analyt Technol Biomed Life Sci

2002 Jan 25

Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.

Kiesewetter DOJagoda EMStarrett JEGribkoff VKHewawasam PSrinivas NSalazar DEckelman WC

Nucl Med Biol

2002 Jan